Unlock the potential of Serotonin Supplements to naturally elevate your mood with this comprehensive guide.
Specific amino acids, vitamins, minerals, and herbs effectively raise serotonin levels, helping to reduce depression and other mental health disorders.
Serotonin-boosting supplements are an effective, non-drug option for increasing serotonin, a major neurotransmitter largely responsible for a positive mood.
Many mental health disorders are linked to low serotonin levels, including depression, anxiety, autism, ADHD, bipolar disorder, sleep disorders, and schizophrenia.
The first-line medical treatment for depression is prescription antidepressant medications which work by increasing serotonin levels in the brain.
However, the most common serotonin-boosting drugs, selective serotonin reuptake inhibitors (SSRIs), can have serious side effects and don’t work for about half of those who try them.
Serotonin supplements can be a viable option.
How Supplements Increase Serotonin Naturally
Before trying any serotonin-enhancing supplements, it’s important to understand a little bit about them, especially how different supplements work together.
There are many kinds of nutritional supplements that increase serotonin levels by various mechanisms.
Some provide building blocks of serotonin, such as amino acid precursors.
Others are essential cofactors required for the synthesis of serotonin.
“ One study concluded that everyone with depression should be taking folic acid (vitamin B6) along with vitamin B12 since the potential benefits are so great.
Some have their own natural antidepressant properties, while others work synergistically with other serotonin-boosting substances.
Amino Acid Serotonin-Boosting Supplements
Some of the most widely used supplements for increasing serotonin are amino acids, the building blocks of proteins.
The first two, tryptophan and 5-HTP, are precursors to serotonin, as illustrated in the image below.
Image courtesy of Dr. Katherine Chung
Later, we’ll discuss vitamins and minerals (in the green boxes above) that are cofactors needed to synthesize serotonin.
1. Tryptophan
Tryptophan is an amino acid commonly found in protein-rich foods such as animal products.
Since tryptophan is a precursor to serotonin, eating foods containing tryptophan would seem to be a sound approach to boosting serotonin.
But surprisingly, less than 1% of tryptophan from food enters the brain, while tryptophan supplements have been shown to effectively increase brain serotonin levels.
This makes tryptophan supplements a better choice than tryptophan-rich foods for boosting serotonin.
2. 5-HTP
5-HTP (5-hydroxytryptophan) is another amino acid that gets converted directly into serotonin, provided the right cofactors are present.
It naturally occurs in substantial amounts in the seeds of Griffonia simplicifolia, a woody African shrub.
Can 5-HTP Supplements Help Anxiety and Depression?
In the US, Canada, and some European countries, 5-HTP is sold as an over-the-counter supplement most commonly used for depression and appetite suppression, and as a sleep aid.
Unfortunately, this supplement’s usefulness for depression may be more hype than substance.
A review of 108 studies on 5-HTP revealed that there is still no definitive evidence that it helps depression.
Tryptophan or 5-HTP? An Ongoing Debate
There’s an ongoing discussion in the natural health community about whether it’s better to take tryptophan or 5-HTP supplements to increase serotonin levels.
Tryptophan more readily enters the brain, but 5-HTP requires one less step to be converted into serotonin.
The evidence currently favors tryptophan supplements.
First, as noted above, studies have not found conclusively that 5-HTP helps depression.
Next, 5-HTP is not recommended for long-term use.
Most people find that 5-HTP stops working within a few months and quitting can cause a cascade of negative side effects.
And finally, while 5-HTP does increase serotonin levels, it does so at the expense of dopamine, another neurotransmitter critical for positive mood.
Conversely, tryptophan actually increases dopamine, along with feel-good endorphins.
Folic acid deficiency, in turn, can cause low serotonin levels.
Folic acid works as an antidepressant by modulating serotonin receptor activity in the brain.
One study concluded that everyone with depression should be taking folic acid along with vitamin B12 since the potential benefits are so great.
Folic acid enhances the effects of SAM-e and antidepressant medications such as Prozac.
6. Vitamin C
Vitamin C is another serotonin cofactor that can act as a natural antidepressant.
One study found that participants who were given vitamin C reported feeling happier, often within as little as one week.
Vitamin C is also required to produce dopamine, norepinephrine, and epinephrine — neurotransmitters that boost physical and mental energy and feelings of reward and satisfaction.
7. Vitamin D
Vitamin D, the “sunshine” vitamin,is one ofthe most important vitamins for the brain and mood.
Deficiency is rampant, with an estimated 1 billion people worldwide having insufficient levels.
A low level of vitamin D is thought to be responsible for the type of depression known as winter blues, or seasonal affective disorder, that many people feel in the winter.
Serotonin Deficiency: Signs, Symptoms, Solutions
Vitamin D regulates the conversion of tryptophan into serotonin.
If you spend most of your time indoors or live in the northern half of the US, vitamin D supplementation is a must.
Tip: Take vitamin D along with a fish oil supplement. Researchers have discovered that they work synergistically to optimize serotonin levels.
8. Magnesium
Magnesium is a mineral that’s essential in over 600 different metabolic functions, including nervous system regulation.
It’s deficiency is linked to lower serotonin levels.
Patients treated with magnesium supplements have experienced rapid recovery from major depressive disorder.
Besides improving mood, magnesium has also been found to increase focus and concentration, energy, and resilience to stress.
Magnesium deficiency is widespread, with up to 75% of Americans not getting enough.
9. Zinc
Zinc is another essential mineral with antidepressant properties.
It’s normally present in high concentrations in the brain where it assists many brain functions.
Zinc increases the uptake of serotonin in certain areas of the brain and shows potential as a treatment for major depressive disorder.
Zinc deficiency is extremely common and is believed to affect 2 billion people worldwide.
Children, older people, and vegetarians are most at risk for zinc deficiency.
Food-Based Supplements That Raise Serotonin Levels
There are a few serotonin-boosting compounds that naturally occur in food.
Theoretically, you could raise your serotonin level from diet alone if you consumed enough of the right foods, but that’s often not practical.
Instead, you can take supplements that are derived from these serotonin-boosting foods.
10. L-Theanine
L-theanine is a brain health-promoting amino acid found almost exclusively in true teas — white, green, oolong, and black — that come from the leaves of the Camilla sinensis plant.
It increases brain levels of serotonin and can improve resilience to stress.
[How to increase serotonin by strategic carbohydrate consumption.]
It has the unique ability to increase alpha brainwave activity, inducing a brainwave state similar to that achieved during meditation.
You can get l-theanine by drinking tea or taking a theanine supplement.
11. Omega-3s
Omega-3 essential fatty acids (EFAs) are found mainly in cold-water, fatty fish like salmon and mackerel.
Omega-3s are one of the most important groups of nutrients for overall brain health and function.
They’re essential for building healthy brain cells and promoting new brain cell formation.
People with low serotonin levels commonly have low levels of omega-3 EFAs.
Two major types of omega-3s are DHA (docosahexaenoic acid) and EPA (eicosapentaenoic acid), both of which are involved with serotonin activity.
DHA makes serotonin receptors more receptive, while EPA increases the release of serotonin from neurons.
DHA generally holds the distinction of being considered the most crucial of the omega-3s for brain health and function.
Depression, anxiety, bipolar disorder, schizophrenia, memory loss, and attention disorders are linked to low levels of DHA.
You could get enough omega-3s from your diet if you ate fatty fish every day, but few of us do.
Almost everyone can benefit from an omega-3 supplement, such as fish oil, krill oil, or algal oil, as 80% of the world’s population is omega-3 deficient.
12. Probiotics
Probiotics are health-promoting bacteria found in fermented foods like yogurt, kefir, and unpasteurized sauerkraut.
They can help establish a normal balance between good and bad bacteria in the intestines, and that is surprisingly relevant to the health and function of the brain.
Interestingly, the intestines, not the brain, synthesize 90% of the body’s total serotonin.
Dysbiosis, an excess of harmful gut bacteria, generates lipopolysaccharides, toxic byproducts in the gut.
Herbal Supplements That Increase Serotonin
These supplements, derived from plants, don’t usually constitute food but serve to enhance serotonin levels.
13. Curcumin
Curcumin is the active ingredient in the spice turmeric which has many brain-healthy properties.
This compound increases levels of both serotonin and dopamine.
Curcumin supplements have proven to be as effective for depression as the antidepressant Prozac.
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Most commonly, curcumin supplements contain piperine, a compound found in black pepper that increases curcumin absorption by up to 2,000%.
14. Garcinia Cambogia
Traditional Asian cuisine utilizes the sour tropical fruit for its distinctive flavor and culinary purposes.
Garcinia extract has become a popular weight loss supplement that purportedly works by decreasing appetite while increasing the body’s ability to burn fat.
Studies show that it’s minimally effective as a fat burner, but it does suppress appetite by increasing serotonin levels.
It may also help with weight loss by improving mood, thereby reducing emotional eating.
If you are taking a selective serotonin reuptake inhibitor for depression, do not take garcinia as this combination can lead to serotonin toxicity.
15. Rhodiola Rosea
Rhodiola rosea goes by many common names — Arctic root, golden root, rose root, western roseroot, Aaron’s rod, and king’s crown — to name a few.
And it has almost as many uses as it has names.
Since ancient Greek times, people have used Rhodiola to enhance overall physical and mental vitality.
Considered an adaptogen, it’s a natural substance that enhances resistance to stress.
By increasing serotonin, Rhodiola rosea helps with a wide range of brain-related disorders, including depression, anxiety, seasonal affective disorder (SAD), and memory loss.
It has virtually no negative side effects and can reduce depression more quickly than antidepressant medications.
Rhodiola boosts physical energy, so if you have brain fog, trouble concentrating, low energy with depression, or stress-induced fatigue, Rhodiola is an excellent herb to consider.
Safety Warning When Using Supplements to Boost Serotonin
Pharmaceutical medications such as selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), monoamine oxidase inhibitors (MAOIs), and tricyclic antidepressants (TCAs) all work by increasing serotonin levels in the brain.
Combining some serotonin supplements with prescription antidepressants or each other may not be safe, despite their individual safety.
It’s possible to raise your serotonin level too high, putting you at risk of a potentially dangerous condition known as serotonin syndrome.
Symptoms of serotonin syndrome include high fever, irregular heartbeat, and seizures.
Warning: If you experience any of these symptoms or suspect you have serotonin syndrome, seek medical attention immediately.
While most serotonin-boosting supplements will not cause this problem, three that can are the amino acids tryptophan, 5-HTP, and SAM-e.
Using these supplements to wean off antidepressant medication tempts many people, who don’t realize the hazards of combining them.
It is not safe to mix these supplements with prescription antidepressants or with each other.
[The most common cause of excess serotonin by far is the use of prescription antidepressants.]
One should take serotonin syndrome very seriously since symptoms range from mild to fatal.
Prescription antidepressants aren’t the only drugs that can raise serotonin levels too high.
To confirm if any drugs you’re now taking can contribute to high serotonin levels, review or download Medications That Raise Serotonin Levels, a comprehensive list of prescription medications created for us by the consumer advocacy organization Drugwatch.com.
If you have any doubts as to whether you should be taking any of these supplements, we urge you to talk to your doctor, pharmacist, or other knowledgeable health care professional.
Also read our blog on Lion’s Mane Mycelium
