L-Citrulline vs. L-Citrulline DL-Malate: Which Is Best?

L-Citrulline vs. L-Citrulline DL-Malate: Which Is Best?


There are three dietary amino acids involved in the urea cycle: L-Citrulline, L-ornithine and L-arginine. L-Citrulline turns into arginine when it enters the body, making it a potentially beneficial supplement for supporting your arginine levels.

Citrulline is found in a variety of foods. Watermelons in particular carry the highest natural concentration of Citrulline where it’s present in both the fruit’s meat and the rind! Citrulline is also present in some legumes such as, garbanzo beans, soy, and peanuts. In terms of meat, it’s found in high concentrations in the liver but in smaller amounts in red meat and salmon.

Since the concentration of L-Citrulline varies in foods, many look towards supplementation to increase the amount of L-Citrulline in the body. Some use L-Citrulline in various forms, while others use L-citrulline DL-Malate. By looking deeper into how these two compounds work, we can determine which of the two might work best for you.


As discussed, Citrulline is a critical precursor to arginine. Arginine then converts to nitric oxide and more Citrulline by nitric oxide synthase.

You may ask yourself “wouldn’t taking arginine supplements increase arginine levels?” The answer is found in arginase, which is an enzyme found in the stomach and intestines. Arginase breaks down arginine directly into ornithine and urea, neither of which are involved in forming nitric oxide. Arginine supplements break down in the stomach and intestines before getting absorbed and reaching the blood. Arginine supplements may elevate levels initially, but the effect will taper off quickly. Citrulline and Citrulline Malate supplements promote the levels of arginine in your plasma over a longer period of time.

L-Citrulline vs. L-Citrulline DL-Malate: Which Is Best?



Research shows Citrulline and its effects on arginine levels may increase nitric oxide levels and may also support cardiovascular health. The molecular compound nitric oxide aids in transmitting signals to the cells allowing for intercellular communication. Nitric oxide is a molecular compound that’s primarily involved in helping cells transmit signals, allowing for effective cell to cell communication. Nitric oxide also helps support circulation. This effect contributes to Citrulline’s impact on blood flow, promoting cardiovascular health, and supporting the immune system.

Because of its potential for muscle-building benefits, nitric oxide is popular among athletes. The increase in blood flow may promote muscle recovery quicker as well as achieve growth. The blood flow may also deliver more nutrients to the muscle tissue. Research conducted on cyclists suggested that nitric oxide may promote endurance and support longer training sessions by combating lactic acid buildup, which is the cause of muscle fatigue.

Neural functions such as short and long term memory may be enhanced with the increase of circulation from Citrulline and nitric oxide. This may result in promoting both short- and long-term, and memory recall.

L-Citrulline may also support your metabolism. Studies indicate that L-Citrulline may contribute to increased strength and leaner, larger muscles. This may support efforts in losing weight.

L-Citrulline vs. L-Citrulline DL-Malate: Which Is Best?


L-Citrulline DL-malate is Citrulline with a malic acid component added to it. Malate, also known as malic acid, is a compound that occurs naturally in many fruits. It is mostly used as a food additive or preservative.

The combination of Citrulline and malic acid has been shown to promote better absorption and increased bioavailability. However, some studies have shown that malic acid, on its own, has demonstrated potential to support pain management and promote increased physical energy. Many skincare products also include malic acid for its potential exfoliating properties.

L-Citrulline vs. L-Citrulline DL-Malate: Which Is Best?


For most people, the preferred natural nootropic tends to be L Citrulline DL Malate since it may increase arginine and nitric oxide levels while also promoting energy output from the malic acid. This offers a double benefit that many bodybuilders and athletes look for. However, if you aren’t looking for the energy promoting and other benefits from malic acid, then Citrulline may be beneficial for you on its own. The choice ultimately comes down to what each person’s individual needs are.

Why Choose Citrulline Malate With A 2:1 Ratio?

Some dietary supplement vendors will offer Citrulline Malate with more malic acid than Citrulline. This imbalanced ratio may lower the quality of effects. The recommendation is that you find Citrulline Malate with a two to one ratio, meaning twice the grams of Citrulline for every gram of malate. You can find L-Citrulline DL-Malate 2:1 Powder at, ensuring a proper ratio in this nootropic supplement.


The Dynamine Methylliberine in this pre-workout mix will take effect rapidly and in conjunction with CoQ10, Cordyceps 10:1 and Caffeine with L- Theanine. It will help support your endurance through long workouts. Creatine taken daily, and Citrulline DL Malate, helps promote strength and endurance. This is a simple, no-frills pre-workout formulation. Try it and share your experience with us!

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