Nootropics

What You Might Not Know About Panax Ginseng

What You Might Not Know About Panax Ginseng

What is Panax Ginseng?

Ginseng is one of the most well known herbs in the world. It’s immensely important in traditional Chinese use, and has slowly but steadily rooted itself in the Western world. Speaking of roots, what we have come to know of as ‘Ginseng’ is the fleshy fork shaped root of the plant Panax ginseng. This is just one of 11 species in the genus ‘Panax’. The species in the genus Panax are characterized in part by the presence of ginsenosides in their leaves and roots. There are over 30 ginsenosides; each of which have a unique effects in the body. Due to this, it is not surprising that Carl Linnaeus named the genus ‘Panax’ in order to capture the concept of ‘panacea’, a substance that is all-healing.

Not all Panax Ginseng is created equal.

The fact that there are 11 different species in the genus panax brings us to one of the first, and arguably most crucial, facts about  panax ginseng that is often overlooked. Since all panax species contains at least one of the 30 ginsenosides, it is very easy for species to get mixed up through conventional analytical methods; such as UV-VIS. This means that not all “panax ginseng” is actually panax ginseng. It could very well be that what is being sold as panax ginseng is actually the much cheaper to produce panax quinquefolius; which is better known as American ginseng. In fact, many of the panax ginseng products on the market, either knowingly or unknowingly, are mislabeled American ginseng. Some companies do it to save money, while others are just not knowledgeable enough to be able to tell the difference.

There is only one truly accurate way to be sure whether or not we are dealing with real panax ginseng, and that is to run a sample of suspected panax ginseng through HP-TLC, or high performance thin layer chromatography.

Even though every species of panax contains ginsenosides, all of the species have a unique ‘fingerprint’, which can be accurately picked up with HP-TLC. First a reference ‘fingerprint’ is created for panax ginseng. Then a sample of suspected panax ginseng is run through HP-TLC. Afterwards, the sample fingerprint is compared to the reference fingerprint. If they match, then we are dealing with genuine panax ginseng. If they do not, then we are either dealing with one of the other 11 species of ginseng, or a completely different plant altogether. In addition to species analysis, HP-TLC is able to tell which part of the plant was used to make the extract. So you can determine if leaf, root, or stem materials were used. This is extremely crucial, as the types, amounts, and ratios of active ingredients differs wildly between the parts of the plant.

However, the amounts and ratios are very different; which is why we offer both a leaf and root extract separately. Here at Noo-tropcis.eu all of our panax ginseng is evaluated with HP-TLC, so you can be absolutely certain that you will consistently receive genuine panax ginseng.

Panax Ginseng Ginsenosides

So you’ve made it this far into the article and are probably starting to wonder: if all panax species contain ginsenosides, and these ginsenosides are what I’m after, then why do I care which panax species I’m consuming? To answer that question, we’ll first have to examine the variance of effects between the six main ginsenosides, and their metabolites.

Ginsenosides mainly exist as either 20(S)–protopanaxadiols (PPDs) or 20(S)–protopanaxatriols (PPTs). The main chemical difference between them is the presence of sugar side chains at C3, C6 and C20. Variations in these side chain sugars determine where the ginsenosides will bind in the body, and how they will eventually be metabolized. In general, it has been found that PPD’s tend to bind to estrogen receptors (ER) and metabolize to Rg3, whilst PPT’s tend to bind to the glucocorticoid receptors (GR) and metabolize to Rh1.

To put it fairly simplistically for the time being, panax ginseng contains high concentrations of PPT’s and low concentrations of PPD’s, whilst the reverse is true for American ginseng. Thus, panax ginseng has the potential to be more stimulating; due to PPT’s affinity towards the glucocorticoid receptors. Whilst American ginseng has the potential to be more calming; due to PPD’s affinity towards estrogen receptors. In addition to this, there are other major difference between PPT’s and PPD’s in terms of effects, bioavailability, half-life, and metabolic products. To create a more accurate picture of the differences in effects between panax ginseng and American ginseng, we’ll take a look at a couple of the main ginsenosides present in Panax Ginseng.

Protopanaxatriols

Ginsenoside Rg1

This ginsenoside is present in high concentrations in  panax ginseng, but only present in American ginseng in very low concentrations. Like the majority of non-metabolized ginsenosides, Rg1 is glycosylated at C6 and C20. Due to this, Rg1 has a high molecular weight and is hydrophobic, which causes it to have a fairly low bioavailability of 1.9-18.4 %. Luckily, Rg1 eventually becomes deglycosylated to its aglycone Rh1 that reportedly has superior bioavailability. On top of this, Rg1 is the aglycone of Re which is one of the main PPT’s present in panax ginseng. Taking this into account, it can likely be assumed that despite its low bioavailability, Rg1 will display significant biological activity.

One of the main mechanisms of action behind the biological activity of Rg1 appears to be its affinity to the glucocorticoid receptor (GR). Activation of GR is responsible for many aspects of our ‘fight or flight’ response, and thus significantly contributes to our perceived feeling of stress. Rg1 appears to have a modulatory effect on GR, by being a partial agonist. During periods of low activation of GR by endogenous ligands, Rg1 can produce a minor ‘fight or flight’ response. During periods of high activation by endogenous ligands, Rg1 occupies the receptor and activates it to a much lower extent than the endogenous ligand would (Leung & Wong, 2010). Thus, Rg1 maintains an adequate level of stress. We say adequate level because stress follows a bell shaped response curve. Too little stress, and our motivation and alertness plummets. If our stress levels are too high, we become overwhelmed and shut down. However, if we hover right at the top of the bell curve, then we can reap the benefits of enhanced motivation and alertness. This effect on GR is likely what causes panax ginseng to produce a mild stimulatory effect. 

Ginsenoside Re

Re is another PPT that is very promising. It has been shown to significantly increase extracellular levels of acetylcholine and dopamine.These two neurotransmitters support memory, learning, alertness and motivation. However, Re has very poor bioavailability of 0.19 % – 7.06 %, in addition to this the small amount that does get absorbed is very quickly metabolized. To be precise, after administration of Re to rats via a subcutaneous injection, Re was completely undetectable in just 240 minutes. This means that Re has an incredibly short half live and thus we can’t be completely sure how significant of an effect Re has after oral administration in humans. Luckily Re is quickly metabolized to Rg1, thus possibly contributing to the amount of Rg1 that makes it to the brain since Re has been shown to exhibit excellent BBB permeability.

Protopanaxadiols

The protopanaxadiol (PPD) ginsenoside content is lower in Panax Ginseng, but higher in American Ginseng. These consist of Rb1, Rb2, Rc, Rd, and Rg3. These ginsenosides have lower affinities for the glucocorticoid receptor (GR), and higher affinity for the estrogen receptor (ER). It’s these differences in affinity that really alter the subjective difference in effects between extracts derived from the two species. This is also why traditional Chinese use considers American Ginseng to be on the “Yin” side, while the more stimulating Panax Ginseng is on the “Yang.” Not surprisingly, Yin energy is said to be the more feminine trait, while Yang to be the masculine. With the glucocorticoid and estrogen receptor affinities taken into account, it is no wonder the Chinese categorized the two plants the way they did. We will go into more detail about the individual protopanaxadiols in a later article on American Ginseng.

Summary

So as you can see, looking at the percentage of total ginsenosides in a ginseng extract is really missing most of the detail needed to fully understand the effects one will receive. The protopanaxatriol ginsenosides present in Panax Ginseng are going to lead to much more stimulating effects on the body. It’s really Rg1 and Re that give the stimulating effects most people associate with the plant. Standardization to those two is going to determine just how effective an extract it is at increasing energy. While Rg1 and Re are present in the roots, and that is the most common plant part used in supplements, they are found in much higher concentrations in the leaves. Similarly, these two ginsenosides are very low in American Ginseng. With American Ginseng being very often mislabeled as Panax Ginseng, due to incorrect analytical testing methods, or a lack of understanding regarding the nuances of the various ginsenosides, one can see why there is so much variability in people’s reported effects from the supplements they take. American Ginseng is much cheaper to produce as well. So it is an attractive option for less scrupulous vendors to substitute. This not only has the unintended side effect of hurting people’s view of the effectiveness of Panax Ginseng products, but also artificially deflates the perceived value of the plant. Real Panax Ginseng is an amazing supplement for energy, focus, and memory, and should be considered a cornerstone of many natural supplement regimens.

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